Bi-specific T1 positive-contrast-enhanced magnetic resonance imaging molecular probe for hepatocellular carcinoma in an orthotopic mouse model

Figure 5 Time-dependent increasing rates of T1- and T2-weighted T/B signal ratios. Increasing rates of T1- and T2-weighted T/B signal ratio at different time points (12, 24, and 32 h) post-injection as compared with pre-injection (0 h) of the U, anti-alpha-fetoprotein (AFP)-ultra-small superparamagnetic iron oxide (USPIO), anti-glypican-3 (GPC3)-USPIO, and anti-AFP-USPIO-anti-GPC3 probes. Data points represent averaged rates from two mice if the image quality was acceptable. A: T1-weighted T/B signal ratios; B: T2-weighted T/B signal ratios. UA: Anti-AFP-USPIO; UG: Anti-GPC3-USPIO; UAG: Anti-AFP-USPIO-anti-GPC3.