Bi-specific T1 positive-contrast-enhanced magnetic resonance imaging molecular probe for hepatocellular carcinoma in an orthotopic mouse model

Figure 2 Magnetic resonance imaging properties of ultra-small superparamagnetic iron oxide phantoms. A: T1- and T2-weighted images of a series of 0.9% saline water solutions containing different concentrations of the ultra-small superparamagnetic iron oxide probes as indicated by iron concentration; B: Changes in the T1- and T2-weighted signal intensities according to iron concentration, with standard deviation also illustrated; C: T1 and T2 map illustrated in pseudo color under different iron concentration; D: Linear regression fitting of the longitudinal relaxation-rate (1/T1); E: transversal relaxation-rate (1/T2) data vs different iron concentrations (with standard deviation also illustrated) for extracting the longitudinal relaxivity (r₁) and transverse relaxivity (r₂), respectively.