Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α

Figure 4 Berberine inhibited β-catenin expression in MGC803 and SGC7901 xenograft tumor models. A: Immunohistochemistry showed that berberine reduced the expression of β-catenin in tumor tissues of MGC803 and SGC7901 xenograft tumor models; B: The quantification of immunohistochemistry of the expression of β-catenin in tumor tissues of MGC803 and SGC7901 xenograft tumor models; C: The effect of berberine on β-catenin mRNA alteration in tumor tissues of MGC803 and SGC7901 xenograft tumor models; D: The effect of berberine on β-catenin protein expression in tumor tissues of MGC803 and SGC7901 xenograft tumor models; E: The effect of berberine on β-catenin mRNA in liver tissues of MGC803 and SGC7901 xenografts; F: The effect of berberine on β-catenin protein expression in liver tissues of MGC803 and SGC7901 xenografts. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001; ^dP < 0.0001. Ctrl: The control group; BBR: The berberine group.