Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α

Figure 3 Berberine inhibited WNT5a expression in MGC803 and SGC7901 xenograft tumor models. A: Immunohistochemistry showed that berberine reduced the expression of WNT5a in tumor tissues of MGC803 and SGC7901 xenograft tumor models; B: The quantification of immunohistochemistry of the expression of WNT5a in tumor tissues of MGC803 and SGC7901 xenograft tumor models; C: The effect of berberine on WNT5a mRNA level in tumor tissues of MGC803 and SGC7901 xenograft tumor models; D: The effect of berberine on WNT5a protein expression in tumor tissues of MGC803 and SGC7901 xenograft tumor models; E: The effect of berberine on WNT5a mRNA expression in liver tissues of MGC803 and SGC7901 xenografts; F: The effect of berberine on WNT5a protein expression in liver tissues of MGC803 and SGC7901 xenografts. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. Ctrl: The control group; BBR: The berberine group.