Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer

Table 5 Prognostic factors of patients with gastric cancer by univariate and multivariate analyses based on logistic regression analysis in the infiltrative growth type group

Characteristics	INFc
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex		0.570
Male	1
Female	0.889 (0.592-1.335)
Age (yr)	1.028 (1.009-1.047)	0.003	1.026 (1.004-1.049)	0.021
BMI	0.965 (0.915-1.017)	0.184
PLR	1.007 (1.004-1.010)	< 0.001	1.004 (1.001-1.008)	0.021
ALT	0.984 (0.966-1.003)	0.096
Total protein	0.995 (0.973-1.018)	0.683
CEA	1.006 (0.998-1.014)	0.161
CA19-9	1.000 (1.000-1.006)	0.020	1.001 (0.999-1.004)	0.387
Borrmann type		< 0.001		0.055
0-1	1		1
2	2.104 (0.574-7.708)	0.262	1.193 (0.290-4.903)	0.807
3	4.298 (1.233-14.981)	0.022	1.781 (0.460-6.891)	0.403
4-5	14.250 (3.837-52.919)	< 0.001	3.735 (0.835-16.696)	0.085
Tumor location		< 0.001		0.059
Lower third	1		1
Middle third	2.791 (1.669-4.670)	< 0.001	1.952 (1.052-3.622)	0.034
Upper third	1.985 (0.947-4.160)	0.069	1.955 (0.820-4.658)	0.130
Entire stomach	22.330 (2.867-173.902)	0.003	4.687 (0.523-41.965)	0.167
Tumor size (mm)	1.028 (1.020-1.037)	< 0.001	1.004 (0.993-1.016)	0.433
pTNM stage		< 0.001		0.028
I	1		1
II	10.667 (1.405-80.956)	0.022	8.549 (1.073-68.125)	0.043
III	45.208 (6.106-334.716)	< 0.001	13.795 (1.693-112.382)	0.014
Histological types		0.643
Well and medium differentiation	1
Poor differentiation	1.026 (0.656-1.604)	0.912
Others	0.826 (0.493-1.384)	0.468
mLNR	93.645 (30.921-283.603)	< 0.001	11.042 (2.407-50.664)	0.002
Vascular infiltration		< 0.001		0.783
No	1		1
Yes	2.899 (1.905-4.411)		1.080 (0.623-1.874)
Nerve infiltration		0.029		0.471
No	1		1
Yes	1.524 (1.044-2.226)		1.187 (0.745-1.892)
Postoperative chemotherapy		0.315
Yes	1
No	0.891 (0.554-1.209)

Carcinoembryonic antigen and carbohydrate antigen 19-9 were according to the tumor marker examination. Tumor infiltrative pattern, tumor location, postsurgical tumor node metastasis stage, histological type, metastatic lymph node ratio, vascular infiltration and nerve infiltration were according to the postoperative pathology report. Statistically significant P values are in bold (P < 0.05). INF: Tumor infiltrative pattern; INFa: Expansive growth type; INFb: Intermediate type; INFc: Infiltrative growth type; HR: Hazard ratio; BMI: Body mass index; PLR: Platelet–lymphocyte ratio; ALT: Alanine transaminase; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; mLNR: Metastatic lymph node ratio; pTNM: Postsurgical tumor node metastasis.