Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer

Table 4 Prognostic factors of patients with gastric cancer by univariate and multivariate analyses based on logistic regression analysis in the intermediate type group

Characteristics	INFb
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex		0.115
Male	1
Female	0.617 (0.339-1.124)
Age (yr)	1.033 (1.007-1.061)	0.014	1.036 (1.004-1.069)	0.026
BMI	0.814 (0.746-0.888)	< 0.001	0.861 (0.781-0.950)	0.003
PLR	1.008 (1.003-1.012)	< 0.001	1.006 (1.001-1.012)	0.018
ALT	0.976 (0.949-1.004)	0.094
Total protein	0.975 (0.946-1.004)	0.092
CEA	1.004 (0.995-1.014)	0.338
CA19-9	1.003 (1.001-1.006)	0.012	1.000 (0.998-1.003)	0.650
Borrmann type		0.005		0.226
0-1	1		1
2	1.031 (0.430-2.473)	0.945	0.715 (0.246-2.079)	0.538
3	2.410 (1.081-5.372)	0.031	1.530 (0.554-4.223)	0.412
4-5	3.182 (1.201-8.429)	0.020	1.339 (0.374-4.797)	0.654
Tumor location		0.088	-	-
Lower third	1
Middle third	1.195 (0.641-2.228)	0.575
Upper third	1.527 (0.697-3.345)	0.290
Entire stomach	7.634 (1.441-40.446)	0.017
Tumor size (mm)	1.021 (1.012-1.032)	< 0.001	1.007 (0.994-1.021)	0.302
pTNM stage		< 0.001		< 0.001
I	1		1
II	3.929 (1.120-13.785)	0.033	2.036 (0.528-7.856)	0.302
III	23.010 (6.895-76.795)	< 0.001	8.306 (2.053-33.597)	0.003
Histological types		0.739
Well and medium differentiation	1
Poor differentiation	1.105 (0.617-1.977)	0.738
Others	0.853 (0.472-1.542)	0.599
mLNR	87.343 (18.612-409.881)	< 0.001	2.267 (0.291-17.641)	0.434
Vascular infiltration		< 0.001		0.149
No	1		1
Yes	3.160 (1.897-5.263)		1.585 (0.848-2.963)
Nerve infiltration		0.003		0.859
No	1		1
Yes	2.097 (1.283-3.428)		1.057 (0.573-1.951)
Postoperative chemotherapy		0.493
Yes	1
No	0.823 (0.472-1.436)

Carcinoembryonic antigen and carbohydrate antigen 19-9 were according to the tumor marker examination. Tumor infiltrative pattern, tumor location, postsurgical tumor node metastasis stage, histological type, metastatic lymph node ratio, vascular infiltration and nerve infiltration were according to the postoperative pathology report. Statistically significant P values are in bold (P < 0.05). INF: Tumor infiltrative pattern; INFa: Expansive growth type; INFb: Intermediate type; INFc: Infiltrative growth type; HR: Hazard ratio; BMI: Body mass index; PLR: Platelet–lymphocyte ratio; ALT: Alanine transaminase; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; mLNR: Metastatic lymph node ratio; pTNM: Postsurgical tumor node metastasis.