Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer

Table 3 Prognostic factors of patients with gastric cancer by univariate and multivariate analyses based on logistic regression analysis in the expansive growth type group

Characteristics	INFa
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex		0.584
Male	1
Female	1.261 (0.550-2.894)
Age (yr)	1.019 (0.979-1.061)	0.349
BMI	0.880 (0.772-1.003)	0.055
SII	1.002 (1.001-1.003)	0.001	1.001 (1.000-1.003)	0.039
ALT	0.988 (0.954-1.023)	0.491
Total protein	0.968 (0.916-1.023)	0.251
CEA	1.030 (0.996-1.065)	0.087
CA19-9	1.002 (0.998-1.006)	0.278
Borrmann type		0.007		0.272
0-1	1		1
2	3.818 (0.448-32.517)	0.220	5.312 (0.450-62.711)	0.185
3	8.947 (1.135-70.530)	0.038	5.450 (0.496-59.870)	0.166
4-5	23.333 (2.525-215.647)	0.005	14.134 (0.944-211.701)	0.055
Tumor location		0.691
Lower third	1
Middle third	1.176 (0.366-3.782)	0.785
Upper third	1.667 (0.167-16.657)	0.664
Entire stomach	5.000 (0.303-82.520)	0.261
Tumor size (mm)	1.032 (1.016-1.049)	< 0.001	1.012 (0.989-1.034)	0.310
pTNM stage		< 0.001		0.796
I	1		1
II	2.615 (0.747-9.159)	0.133	0.660 (0.154-2.830)	0.576
III	10.968 (3.457-34.794)	< 0.001	0.532 (0.080-3.525)	0.513
Histological type		0.160
Well and medium differentiation	1
Poor differentiation	2.282 (0.972-5.360)	0.058
Others	1.617 (0.527-4.959)	0.401
mLNR	438.799 (38.101-5053.535)	< 0.001	471.355 (8.218-27035.275)	0.003
Vascular infiltration		0.080
No	1
Yes	2.065 (0.917-4.647)
Nerve infiltration		0.025		0.621
No	1		1
Yes	2.432 (1.118-5.288)		1.286 (0.474-3.490)
Postoperative chemotherapy		0.720
Yes	1
No	1.159 (0.517-2.597)

Carcinoembryonic antigen and carbohydrate antigen 19-9 were according to the tumor marker examination. Tumor infiltrative pattern, tumor location, postsurgical tumor node metastasis stage, histological type, metastatic lymph node ratio, vascular infiltration and nerve infiltration were according to the postoperative pathology report. Statistically significant P values are in bold (P < 0.05). INF: Tumor infiltrative pattern; INFa: Expansive growth type; INFb: Intermediate type; INFc: Infiltrative growth type; HR: Hazard ratio; BMI: Body mass index; SII: Systemic immune-inflammation index; ALT: Alanine transaminase; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; mLNR: Metastatic lymph node ratio; pTNM: Postsurgical tumor node metastasis.