Review
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Apr 15, 2022; 14(4): 794-807
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.794
Table 2 Roles of sirtuins in esophageal cancer

Type
Role
Effect
Ref.
SIRT1ESCCPromotorSuppression of SIRT1 inhibits cell proliferation, cell migration, and EMT in ESCC cell line[22,23]
SIRT1 expression is associated with poor prognosis[23-27,34]
SIRT1 enhances chemotherapy and chemoradiotherapy resistance[29-32]
Rapamycin suppresses cell viability, migration, invasion by negatively regulating SIRT1[35]
EACSIRT1 is associated with poor overall survival[28]
SIRT1 is a useful biomarker for high-grade dysplasia and cancer of Barrett's esophagus[33]
Sirtinol, SIRT1 inhibitor, inhibits cell viability, affects proliferation in the long term, and potentially suppresses resistant and recurrent tumors under hypoxic conditions[36]
SIRT2ESCCPromotorSIRT2 expression was associated with tumor invasion, lymph node metastasis, advanced clinical stage, poor progression-free survival, and overall survival[47]
EACSuppressorDysregulation of SIRT2 is associated with poor prognosis[48,49]
SIRT3ESCCPromotorSerum SIRT3 levels are higher in ESCC patients compared to those in the control subjects[63]
SIRT3 induces the proliferation inhibition and apoptosis[64]
High SIRT3 expression is associated with poor survival outcome[65,66]
EACNo report
SIRT4ESCCSuppressorSIRT4 rescues the promoting effect of miR-424-5p on ESCC cell proliferation and migration[76]
Low SIRT4 expression is associated with a high distant recurrence rate and poor prognosis, and in vitro, knockdown of SIRT4 promotes cell proliferation and migration[77]
EACNo report
SIRT5ESCCNo report
EAC
SIRT6ESCCPromotorSIRT 6 is overexpressed in ESCC tissues and that it also promotes cell proliferation and induces the expression of Bcl2, an important anti-apoptotic factor, and autophagy in ESCC cells[102]
EACNo report
SIRT7ESCCNo report
EAC