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©The Author(s) 2022.
World J Gastrointest Oncol. Apr 15, 2022; 14(4): 794-807
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.794
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.794
Table 2 Roles of sirtuins in esophageal cancer
Type | Role | Effect | Ref. | |
SIRT1 | ESCC | Promotor | Suppression of SIRT1 inhibits cell proliferation, cell migration, and EMT in ESCC cell line | [22,23] |
SIRT1 expression is associated with poor prognosis | [23-27,34] | |||
SIRT1 enhances chemotherapy and chemoradiotherapy resistance | [29-32] | |||
Rapamycin suppresses cell viability, migration, invasion by negatively regulating SIRT1 | [35] | |||
EAC | SIRT1 is associated with poor overall survival | [28] | ||
SIRT1 is a useful biomarker for high-grade dysplasia and cancer of Barrett's esophagus | [33] | |||
Sirtinol, SIRT1 inhibitor, inhibits cell viability, affects proliferation in the long term, and potentially suppresses resistant and recurrent tumors under hypoxic conditions | [36] | |||
SIRT2 | ESCC | Promotor | SIRT2 expression was associated with tumor invasion, lymph node metastasis, advanced clinical stage, poor progression-free survival, and overall survival | [47] |
EAC | Suppressor | Dysregulation of SIRT2 is associated with poor prognosis | [48,49] | |
SIRT3 | ESCC | Promotor | Serum SIRT3 levels are higher in ESCC patients compared to those in the control subjects | [63] |
SIRT3 induces the proliferation inhibition and apoptosis | [64] | |||
High SIRT3 expression is associated with poor survival outcome | [65,66] | |||
EAC | No report | |||
SIRT4 | ESCC | Suppressor | SIRT4 rescues the promoting effect of miR-424-5p on ESCC cell proliferation and migration | [76] |
Low SIRT4 expression is associated with a high distant recurrence rate and poor prognosis, and in vitro, knockdown of SIRT4 promotes cell proliferation and migration | [77] | |||
EAC | No report | |||
SIRT5 | ESCC | No report | ||
EAC | ||||
SIRT6 | ESCC | Promotor | SIRT 6 is overexpressed in ESCC tissues and that it also promotes cell proliferation and induces the expression of Bcl2, an important anti-apoptotic factor, and autophagy in ESCC cells | [102] |
EAC | No report | |||
SIRT7 | ESCC | No report | ||
EAC |
- Citation: Otsuka R, Hayano K, Matsubara H. Role of sirtuins in esophageal cancer: Current status and future prospects. World J Gastrointest Oncol 2022; 14(4): 794-807
- URL: https://www.wjgnet.com/1948-5204/full/v14/i4/794.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v14.i4.794