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©The Author(s) 2022.
World J Gastrointest Oncol. Apr 15, 2022; 14(4): 794-807
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.794
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.794
Table 1 Roles of sirtuins in cancer control
Role | Effect | Involved pathway or mechanism | |
SIRT1 | Promotor | Promote proliferation | p53, FOXO family member, E2F1, p73, RB, Ku70, SFRP1, SFRP2, GATA4, GATA5, MLH1 |
Inhibit apoptosis | p53, NF-κβ, FOXO3, Ku70, AKT, MAPK, NRF2 | ||
Induce EMT, promote migration and metastasis | ZEB1 | ||
Suppressor | Inhibit tumor formation and proliferation | β-catenin | |
Induce apoptosis | survivin | ||
Inhibit EMT | SMAD4, TGF-β signaling on MMP7 | ||
SIRT2 | Promotor | Promote proliferation | Mediating immune evasion, altering the alkaline environment |
Inhibit apoptosis | cMYC | ||
Promote invasion and migration | Stimulating mitochondrial metabolism, mediating EMT | ||
Suppressor | Inhibit proliferation | Inhibiting fibroblast activity and tumor angiogenesis | |
Inhibit invasion and migration | MMP9, E-cadherin | ||
SIRT3 | Promotor | Inhibit apoptosis and promote proliferation | p53, SHMT2, IDH2 |
Promote invasion and metastasis | Reprogramming fatty acid metabolism | ||
Suppressor | Induce cell arrest and apoptosis | Bcl-2, p53, HIF1α, PDC, SOD2, GOT2 | |
Inhibit EMT and migration | FOXO3A, Wnt / β-catenin pathway | ||
Inhibit tumorigenesis | PDH | ||
SIRT4 | Promotor | Promote proliferation | PTEN |
Suppressor | Inhibit glutamine metabolism and proliferation | mTORC1 pathway | |
Inhibit EMT, invasion and migration | E-cadherin | ||
Induce G1 cell cycle arrest | Cyclin D, cyclin E | ||
SIRT5 | Promotor | Promote proliferation | GLUD1, SHMT2, NRF2, PKM2, SUN2 |
Inhibit mitochondrial apoptosis | Cyt c | ||
Promote autophagy | AMPK–mTOR pathway | ||
Promote invasion and migration | E2F1 | ||
Promote resistance to chemotherapy | SDHA | ||
Suppressor | Inhibit carcinoma development | ACOX1 | |
Inhibit proliferation | SOD1 | ||
Represent protective mechanism for tumor cells | Inhibiting ammonia-induced autophagy | ||
SIRT6 | Promotor | Promote proliferation and inhibit apoptosis | ERK1/2 pathway, AKT |
Promote invasion and migration | ERK1/2/MMP9 signaling | ||
Contribute to cancer development and progression | Regulating autophagy | ||
Suppressor | Inhibit proliferation | PCBP2, ERK1/2 | |
Inhibit Warburg effect | HIF-1α | ||
Induce apoptosis | NF-κβ, Bax, survivin | ||
Inhibit proliferation, invasion and migration | PKM2 | ||
SIRT7 | Promotor | Promote proliferation | ERK1/2, H3K18ac |
Inhibit apoptosis | miR34a, NF-κβ family subunits, mTOR/IGF2 pathway | ||
Promote invasion | Vimentin, fibronectin, E-cadherin, β-catenin | ||
Suppressor | Inhibit proliferation and invasion | SMAD4 | |
Inhibit EMT | TGF-β signaling |
- Citation: Otsuka R, Hayano K, Matsubara H. Role of sirtuins in esophageal cancer: Current status and future prospects. World J Gastrointest Oncol 2022; 14(4): 794-807
- URL: https://www.wjgnet.com/1948-5204/full/v14/i4/794.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v14.i4.794