RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers

Figure 1 Changes in the expression profiles of significantly differentially expressed mRNAs and circular RNAs in 5-fluorouracil-resistant cells and their parental cells. A: Flow chart of the sequencing analysis; B and C: Clustered heat map indicating differences in circular RNA (circRNA) expression profiling between the HCT116 and HCT116 5-fluorouracil (5-Fu) resistant cell lines and the Lovo and Lovo 5-Fu resistant cell lines; D and E: The volcano plot shows the comparison of the circRNA expression profiles between the parental and 5-Fu resistant HCT116 and Lovo cell lines; F: Clustered heat map indicating differences in circRNA expression profiling in both paired cell lines.