Association and prognostic significance of alpha-L-fucosidase-1 and matrix metalloproteinase 9 expression in esophageal squamous cell carcinoma

doi:10.4251/wjgo.v14.i2.498

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World Journal of Gastrointestinal Oncology

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Clinical and Translational Research

World J Gastrointest Oncol. Feb 15, 2022; 14(2): 498-510
Published online Feb 15, 2022. doi: 10.4251/wjgo.v14.i2.498

Table 1 Association of alpha-L-fucosidase-1 and matrix metalloproteinase 9 expression with clinicopathological characteristics in patients with resected esophageal squamous cell carcinoma from Sun Yat-Sen University Cancer Center

Variable	FUCA1 expression			MMP-9 expression
Variable	Low expression (n = 29)	High expression (n = 90)	P value	Low expression (n = 57)	High expression (n = 62)	P value
Age (yr, mean ± SD)	61.2 ± 7.6	58.3 ± 9.2	0.137	59.5 ± 8.4	58.6 ± 9.4	0.587
Female, n (%)	3 (10.3)	18 (20.0)	0.236	6 (10.5)	15 (24.2)	0.058
History of smoking, n (%)	6 (20.7)	33 (36.7)	0.111	45 (78.9)	35 (56.5)	0.009^a
History of alcohol use, n (%)	10 (34.5)	35 (38.9)	0.670	41 (71.9)	33 (53.2)	0.036
Localization, n (%)
Upper	2 (6.9)	12 (13.3)	0.360	5 (8.8)	9 (14.5)	0.555
Middle	20 (69.0)	49 (54.4)		33 (57.9)	36 (58.1)
Lower	7 (24.1)	29 (32.2)		19 (33.3)	17 (27.4)
Grade, n (%)
Well	4 (13.8)	19 (21.1)	0.648	12 (21.1)	11 (17.7)	0.820
Moderately	16 (55.2)	48 (53.3)		31 (54.4)	33 (53.2)
Poorly	9 (31.0)	23 (25.6)		14 (24.6)	18 (29.0)
T stage, n (%)
T1-2	6 (20.7)	22 (24.4)	0.678	12 (21.1)	16 (25.8)	0.541
T3-4a	23 (79.3)	68 (75.6)	0.678	45 (78.9)	46 (74.2)	0.541
Lymphatic invasion, n (%)
Negative (N0)	20 (69.0)	34 (47.8)	0.003^a	31 (54.4)	23 (37.1)	0.067
Positive (N+)	9 (31.0)	56 (62.2)	0.003^a	26 (45.6)	39 (62.9)	0.067
TNM stage, n (%)
I-II	18 (62.1)	35 (38.9)	0.029^a	29 (50.9)	24 (38.7)	0.182
III	11 (37.9)	55 (61.1)	0.029^a	28 (49.1)	38 (61.3)	0.182
Postoperative complication, n (%)
Arrhythmia	5 (17.2)	22 (24.4)	0.421	16 (28.1)	11 (17.7)	0.179
Pneumonia	1 (3.4)	11 (12.2)	0.172	5 (8.8)	7 (11.3)	0.649
Anastomotic leak	0 (0)	11 (12.2)	0.048^a	4 (7.0)	7 (11.3)	0.421
Adjuvant therapy, n (%)	19 (65.5)	61 (67.8)	0.822	36 (63.2)	44 (71.0)	0.365
FUCA1 total score (mean ± SD)	-	-	-	4.3 ± 3.8	7.3 ± 4.1	0.000^a
High FUCA1 expression, n (%)	-	-	-	36 (63.2)	54 (87.1)	0.002^a
MMP-9 total score (mean ± SD)	3.6 ± 2.7	2.3 ± 2.6	0.029^a	-	-	-
High MMP-9 expression, n (%)	8 (27.6)	54 (60.0)	0.002^a	-	-	-

^aP < 0.05.

FUCA1: Alpha-L-fucosidase-1; MMP-9: Matrix metalloproteinase-9; SD: Standard deviation.

Citation: Yu XY, Lin SC, Zhang MQ, Guo XT, Ma K, Wang LX, Huang WT, Wang Z, Yu X, Wang CG, Zhang LJ, Yu ZT. Association and prognostic significance of alpha-L-fucosidase-1 and matrix metalloproteinase 9 expression in esophageal squamous cell carcinoma. World J Gastrointest Oncol 2022; 14(2): 498-510
URL: https://www.wjgnet.com/1948-5204/full/v14/i2/498.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i2.498