Expression of nucleus accumbens-1 in colon cancer negatively modulates antitumor immunity

Figure 3 The effect of nucleus accumbens-1 on CD8⁺ T cells, myeloid-derived suppressor cells and regulatory T cells in the mouse colon cancer tumor microenvironment. A: Flow cytometric detection of the effects of nucleus accumbens-1 (NAC-1), CD8⁺ T cells and MEK inhibitors on the expression of CD8⁺ T cells; B: Statistical analysis of CD8⁺ T-cell expression levels in each group; C: Flow cytometric detection of the effect of NAC-1 on the expression of myeloid-derived suppressor cells (MDSCs); D: Statistical analysis of the expression of MDSCs in each group; E: Flow cytometric detection of the effect of NAC-1 on the expression of regulatory T cell (Treg) cells; F: Statistical analysis of Treg expression in each group (^aP < 0.05, ^bP < 0.01). NAC-1: Nucleus accumbens-1.