Expression of nucleus accumbens-1 in colon cancer negatively modulates antitumor immunity

Figure 2 Effect of nucleus accumbens-1 on the expression of programmed death receptor-1 ligand. A: Effect of nucleus accumbens-1 (NAC-1) on the mRNA expression of programmed death receptor-1 ligand (PD-L1); B: Effect of NAC-1 on the protein expression of PD-L1; C: The effect of PD-L1 on the transcription level of NAC-1; D: The effect of PD-L1 on the translation level of NAC-1; E: The effect of NAC-1 on the full promoter region of PD-L1; F: The effect of NAC-1 on the PD-L1 classic transcription factor binding segment (1:1, 2:1, 5:1, 10:1 are the ratios of CD8⁺ T cells to RKO; ^aP < 0.05). NAC-1: Nucleus accumbens-1; PD-L1: Programmed death receptor-1 ligand.