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Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Dec 15, 2022; 14(12): 2302-2312
Published online Dec 15, 2022. doi: 10.4251/wjgo.v14.i12.2302
Table 1 Studies analyzing the effect of sarcopenia on surgical outcomes of pancreatic cancer
Ref.CountryNo. of patientsImaging modalityLevelTimeDefinition and cutoffSarcopenia prevalence before surgeryTypes of surgeryPerioperative complicationsSurvivalAdditional meaningful findings or comments
Peng et al[24], 2012United States557CTL3Before surgeryTPAI (mm2/m2), lowest quartile: < 564.2 (M), < 414.5 (F)25%PD, DP(-)(+) OSSarcopenia was an independent predictor of survival in multivariable analysis
Amini et al[7], 2015United States763CTL3Before surgeryTPAI (mm2/m2), < 564.2 (M), 414.5 (F); TPVI (cm³/m2), < 17.2 (M), < 12.0 (F)25% by TPAI, 20% by TPVIPD, DP. TP(+) Overall Cx. by TPVI(+) OS by TPVITPVI was a better measure for defining sarcopenia rather than TPAI
Pecorelli et al[9], 2016Italy202CTL3Before surgeryLSMI, < 52.4 cm2/m2 (M), < 38.5 cm2/m2 (F)165%PD(-)NEThe combination of visceral obesity and sarcopenia was a predictor of perioperative Cx
Ninomiya et al[28], 2017Japan265CTL3Before surgeryLSMI, < 43.75 cm2/m2 (M), < 38.5 cm2/m2 (F)64%PD, DP. TP(-)(-)Sarcopenia was an independent prognostic factor only in patients with BMI ≥ 22 kg/m2
Okumura et al[29], 2017 Japan301CTL3Before surgeryLSMI, clinically relevant cutoff: < 47.1 cm2/m2 (M), < 36.6 cm2/m2 (F)40%PD, DP. TP(-)(+) OS and RFSLow muscle attenuation, as well as low muscle mass, was associated with worse OS and RFS
Choi et al[18], 2018 South Korea180CTL3Before and after 60 d of surgeryLSMI, the lowest tertile; < 45.3 cm2/m2 (M), < 39.3 cm2/m2 (F)33%PD, DP(-)(+) OSAccelerated muscle loss after surgery negatively impacts OS
Sugimoto et al[19], 2018 United States323CTL3Before surgeryLSMI, < 55.4 cm2/m2 (M), < 38.9 cm2/m2 (F)62%PD, DP. TPNE(-)Smaller sex-standardized LSMI as a continuous variable is associated with a shorter OS
Gruber et al[10], 2019 Austria133CTL3Before surgeryLSMI, < 52.4 cm2/m2 (M), < 38.5 cm2/m2 (F)159%PD, DP(-)(+) OSObese patients (BMI ≥ 25) with sarcopenia have higher incidence of major post-operative Cx
Ryu et al[30], 2020 South Korea548CTL3Before surgeryLSMI, < 50.18 cm2/m2 (M), < 38.63 cm2/m2 (F)46%PD(-)(+) OS Sarcopenic obesity is a predictive factor for post-operative pancreatic fistula after PD
Rom et al[25], 2022 Israel111CTL3Before surgeryLSMI, the lowest quartile: < 44; 35 cm2/m2 (M), < 34.82 cm2/m2 (F)25%PD, DP(+) Overall Cx.(+) OS, DSS, and RFSHigh intramuscular adipose tissue content correlates with poor OS and DSS