E3 ubiquitin ligase TRIM55 promotes metastasis of gastric cancer cells by mediating epithelial-mesenchymal transition

Figure 1 Representative images of immunohistochemical staining for TRIM55 in human gastric cancer tissue and its prognostic significance. A: Low expression of TRIM55 in gastric normal mucosa tissue; B: TRIM55 expression in well-differentiated adenocarcinoma; C: TRIM55 expression in poorly differentiated adenocarcinoma; D: Overexpression of TRIM55 in signet-ring cell carcinoma. Original magnification, 400 ×; E: TRIM55 protein levels in five tumor samples and their matched normal tissues; F: Overall survival curves for 91 gastric cancer (GC) patients according to TRIM55 protein expression (P = 0.026); G: Overall survival curves of TCGA GC patients with different TRIM55 expression. ^cP < 0.001. HR: Hazard ratio; GC: Gastric cancer.