MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling

Figure 7 MiR-30e-3p inhibits gastric cancer cells growth in vivo. A: BGC-823 cells were transfected with NC, miR-30e-3p mimic and injected subcutaneously into BALB/c nude mice. Sixteen days later, the tumors diameter were analyzed. n = 5 for each group; B: The tumor volume (mm³) was measured after the tumor implantation every other day; C: Sixteen days after the tumor implantation, the tumor weight (g) was measured; D: Sixteen days after the tumor implantation, the relative protein expression of THOC2, PI3K, AKT and mTOR was detected by Western blot. ^aP < 0.05, ^bP < 0.01.