MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling

Figure 1 MiR-30e-3p expression is downregulated in gastric cancer and low expression of miR-30e-3p predicts poor outcome of gastric cancer patients. A: Quantitative real-time polymerase chain reaction (RT-PCR) was performed to analyze the expression of miR-30e-3p in normal human gastric epithelium cell line and four human gastric cancer (GC) cell lines (AGS, MGC803, BGC-823, and MKN45). n = 3 for each group; B: Quantitative RT-PCR was performed to analyze the expression of miR-30e-3p in GC and adjacent non-cancerous tissues. n = 20 for each group; C: Kaplan-Meier survival analysis of prognosis in GC patients with high or low expression of miR-30e-3p. n = 10 for each group. Error bars represented the mean ± SD of more than two independent experiments. ^bP < 0.01.