KLF16 promotes pancreatic adenocarcinoma cell proliferation and migration by positively regulating SMAD6

Figure 5 SMAD6 is a downstream target of Krüppel-like factor 16 in pancreatic adenocarcinoma. A: Volcano analysis of differentially expressed genes with Krüppel-like factor (KLF)16 knockdown in MIA PaCa-2 cells by RNA-seq; B: The top 10 pathways or biological processes of upregulated or downregulated genes; C and D: SMAD6 mRNA and protein levels in pancreatic adenocarcinoma (PAAD) cells with KLF16 knockdown or overexpression. GAPDH used as the internal control; E: The expression of SMAD6 in PAAD from The Cancer Genome Atlas; F: Spearman relationship between KLF16 and SMAD6 in PAAD. ^bP < 0.01; ^cP < 0.001.