Synaptophysin-like 2 expression correlates with lymph node metastasis and poor prognosis in colorectal cancer patients

Figure 1 Synaptophysin-like 2 expression levels and survival analyses in colorectal cancer. A: Synaptophysin-like 2 (SYPL2) expression in 275 colon cancer tissue and 349 normal colon tissue samples and in 92 rectal cancer tissue and 318 normal rectal tissue samples from Gene Expression Profiling Interactive Analysis (GEPIA) (P < 0.05); B: SYPL2 expression in 203 colorectal cancer (CRC) tissue and 160 normal colorectal tissue samples from GSE87211 (P < 0.01); C: SYPL2 expression in 98 CRC samples, 98 adjacent normal samples, and 50 healthy colon tissue samples from GSE44076 (P < 0.001); D: SYPL2 expression in tumor tissues and adjacent normal colon tissue samples from 20 CRC patients who underwent tumor resection at Fuyang People’s Hospital (P < 0.05). The average expression of SYPL2 in the 20 normal tissue samples was regarded as a reference; E: Associations of SYPL2 expression with the overall survival (OS) of CRC patients from GEPIA (P < 0.05); F: Associations of SYPL2 expression with the disease-free survival (DFS) of CRC patients from GEPIA (P < 0.05); G: Associations of SYPL2 expression with the OS of CRC patients from the Kaplan-Meier plotter (P < 0.05); H: Associations of SYPL2 expression with the DFS of CRC patients from the Kaplan-Meier plotter (P < 0.05); I: Associations of SYPL2 expression with the OS of stage II CRC patients from TCGA (P < 0.05); J: Associations of SYPL2 expression with the OS of stage III CRC patients from TCGA (P < 0.05). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. SYPL2: Synaptophysin-like 2; HR: Hazards ratio.