Potential role of long noncoding RNA RP5-881L22.5 as a novel biomarker and therapeutic target of colorectal cancer

Figure 3 Distribution of tumor microenvironment scores, 22 types of immune cells and expression of T lymphocyte coinhibitory receptor genes between different groups. A: ImmuneScore, P = 5.8 × 10^-16; B: StromalScore, P = 0.0047; C: EstimateScore, P = 2.7 × 10^-8; D: The 22 immune cell types were represented in columns, and the proportions of immune cells were represented in rows; E: Expression of CD244, P = 6.8 × 10^-13; F: Expression of CTLA4, P = 2.0 × 10^-8; G: Expression of PDCD1, P = 1.3 × 10^-14; H: Expression of HAVCR2, P = 2.7 × 10^-9; I: Expression of LAG3, P = 8.0 × 10^-16; J: Expression of TIGIT, P = 9.3 × 10^-11. Red referred to the high expression group, and blue referred to the low expression group (grouped by median of RP5-881L22.5 expression). NK: Natural killer; exphigh: Expression high; explow: Expression low.