Potential role of long noncoding RNA RP5-881L22.5 as a novel biomarker and therapeutic target of colorectal cancer

Figure 1 Volcano plot of the differentially expressed genes in The Cancer Genome Atlas-colon adenocarcinoma (LogFC > 1 or < -1 and adjust P value < 0. 05 were defined as significant difference) and results from GEPIA2 website query. A: Volcano plot of mRNA differential expression; B: Volcano plot of long noncoding (lnc) RNA differential expression. Red points referred to upregulated differentially expressed genes; green points referred to downregulated differentially expressed genes; grey points referred to non-differentially expressed genes; C: RP5-881L22.5 expression in the 33 cancers of The Cancer Genome Atlas. Log2FC > 1.0 or < -1.0 and q value < 0.05 were defined as a significant difference. Red points referred to tumor tissues; green points referred to normal tissues; D: Expression level of RP5-881L22.5 among colon adenocarcinoma, rectum adenocarcinoma, stomach adenocarcinoma and esophageal carcinoma (The Cancer Genome Atlas). Red referred to tumor tissues; blue referred to normal tissues (include data of GTEx); “a” referred to log2FC > 1.0 and q value < 0.01. ACC: Adrenocortical carcinoma; BLCA: Bladder urothelial carcinoma; BRCA: Breast invasive carcinoma; CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; DLBC: Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA: Esophageal carcinoma; GBM: Glioblastoma multiforme; HNSC: Head and neck squamous cell carcinoma; KICH: Kidney chromophobe; KIRC: Clear cell renal cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; LAML: Acute myeloid leukemia; LGG: Brain lower grade glioma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; MESO: Mesothelioma; N: Normal; OV: Ovarian serous cystadenocarcinoma; PAAD: Pancreatic adenocarcinoma; PCPG: Pheochromocytoma and Paraganglioma; PRAD: Prostate adenocarcinoma; READ: Rectum adenocarcinoma; SARC: Sarcoma; SKCM: Skin Cutaneous Melanoma; STAD: Stomach adenocarcinoma; T: Tumor; TGCT: Testicular Germ Cell Tumors; THCA: Thyroid carcinoma; THYM: Thymoma; UCEC: Uterine corpus endometrial carcinoma; UCS: Uterine carcinosarcoma; UVM: Uveal melanoma.