A rare synchrony of adenocarcinoma of the ampulla with an ileal gastrointestinal stromal tumor: A case report

Table 5 Management of advanced or metastatic gastrointestinal stromal tumors

Imatinib-sensitive mutations			Imatinib-insensitive mutations
KIT mutations (except exon-9 variety)	Exon-9 KIT mutations		PDGFRA842 V2V mutation	BRAF mutation	NTRK translocation	SDHB	All other mutations
Imatinib 400 mg daily	Imatinib 800 mg daily		Avapritinib	BRAF inhibitor	NTRK inhibitorentrectiniblarotrectinib	Customized management	Sunitinib
Imatinib responsive	Imatinib unresponsive
Surgery of the residual disease and continue imatinib for life	Excision and ablation of progressing lesion	Add and continue sunitinib if responsive