Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

doi:10.4251/wjgo.v14.i11.2195

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Nov 15, 2022; 14(11): 2195-2207
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2195

Table 3 Copy number alterations

CGH-test^a	Chr	Type	Band	Length basepairs	Group comparison	P value^b
2.50%	8	Gain	p11.22-q24.3	106890001	Less in FIT-interval CRCs	0.009
2.50%	20	Gain	p13-p12.1	14520001	More in FIT-interval CRCs	0.039

^aPercentage of information loss accepted at CGH-comparison test.

^bFrequency of altered region in FIT-interval CRCs compared to screen-detected CRCs.

CGH: Comparative genomic hybridization; FIT: Fecal immunochemical test; CRC: Colorectal cancer.

Citation: van der Vlugt M, Carvalho B, Fliers J, Montazeri N, Rausch C, Grobbee EJ, Engeland MV, Spaander MCW, Meijer GA, Dekker E. Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas. World J Gastrointest Oncol 2022; 14(11): 2195-2207
URL: https://www.wjgnet.com/1948-5204/full/v14/i11/2195.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i11.2195