Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

doi:10.4251/wjgo.v14.i11.2195

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Nov 15, 2022; 14(11): 2195-2207
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2195

Table 2 Microsatellite instability analysis and CpG island methylator phenotype analysis

	FIT-interval CRC	SD-CRC	P value
MSI analysis^a
MSI	4 (19%)	5 (12%)	0.469
MSS	17 (81%)	36 (88%)
CIMP analysis^b
Methylated, positive	7 (33%)	8 (21%)	0.274
Unmethylated, negative	14 (66%)	31 (79%)

^an = 62.

^bn = 60.

All values expressed as number and % with respect to fecal immunochemical test-interval and screen-detected colorectal cancers. FIT: Fecal immunochemical test; CRC: Colorectal cancer; SD-CRC: Screen-detected colorectal cancer; MSI: Microsatellite instability; MSS: Microsatellite stable; CIMP: CpG island methylator phenotype.

Citation: van der Vlugt M, Carvalho B, Fliers J, Montazeri N, Rausch C, Grobbee EJ, Engeland MV, Spaander MCW, Meijer GA, Dekker E. Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas. World J Gastrointest Oncol 2022; 14(11): 2195-2207
URL: https://www.wjgnet.com/1948-5204/full/v14/i11/2195.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i11.2195