Disseminated carcinomatosis of the bone marrow caused by granulocyte colony-stimulating factor: A case report and review of literature

Figure 3 Histologic and immunohistochemical images of the primary and relapsed lesions. A: Histology of the primary gastric specimen shows moderately to poorly differentiated adenocarcinoma and, partially, signet cell carcinoma (hematoxylin and eosin); B: On autopsy, the metastatic bone marrow lesion shows corresponding adenocarcinoma (hematoxylin and eosin); C: Immunohistochemical staining for granulocyte colony-stimulating factor receptor (G-CSFR) is negative in the primary lesion; D: Immunohistochemical staining for G-CSFR is diffusely positive in the bone marrow metastatic lesion.