Disseminated carcinomatosis of the bone marrow caused by granulocyte colony-stimulating factor: A case report and review of literature

Figure 1 Clinical course after gastrectomy. During the five-year follow-up of resected gastric cancer, there are no signs of recurrence based on tumor markers, computed tomography, and gastroduodenoscopy. Eight months after completing chemotherapy with granulocyte colony-stimulating factor administration for Ewing sarcoma, disseminated carcinomatosis of the bone marrow (DCBM) from gastric cancer is diagnosed. Alkaline phosphatase is moderately elevated during the treatment of Ewing sarcoma and remarkably increased when the patient complained of lumbar pain, which led to the diagnosis of DCBM.*1: Complaint of pain; *2: Bone marrow biopsy; *3: Died of DCBM. G-CSF: Granulocyte colony-stimulating factor; DCBM: Disseminated carcinomatosis of the bone marrow; ALP: Alkaline phosphatase; VDC/IE: Vincristine, doxorubicin, cyclophosphamide/ifosfamide, etoposide; GC: Gastric cancer.