VCAN, expressed highly in hepatitis B virus-induced hepatocellular carcinoma, is a potential biomarker for immune checkpoint inhibitors

Figure 4 Expression of VCAN mRNA and DNA methylation in patients with hepatitis B virus-related hepatocellular carcinoma and cirrhosis. A: VCAN mRNA expression in the serum of hepatitis B virus (HBV)-related patients and controls; B: VCAN DNA methylation in the blood of HBV-related patients; C: Box diagram of VCAN CpG methylation in HBV-related patients; D: Correlation heatmap between VCAN mRNA and the methylation of each CpG site in blood. ns: P > 0.05, ^aP < 0.05. HCC: Hepatocellular carcinoma.