Transcriptional factor III A promotes colorectal cancer progression by upregulating cystatin A

Figure 1 Transcriptional factor III A expression in colorectal cancer and survival analysis of patients with colorectal cancer. A: Transcriptional factor III A (GTF3A) expression in adjacent normal, colorectal cancer (CRC), and metastatic tissues were detected using immunohistochemical staining. The grading standards were: (1) Negative, a, scored as 0; (2) Weakly positive, b, scored as 1; (3) Moderately positive, c, scored as 2; and (4) Strongly positive, d, scored as 3. Scale bar, 50 μm; B: GTF3A expression in adjacent normal, CRC, and metastatic tissues was quantified using semi-quantitative histological score. Scored dots expression groups were statistically analyzed using unpaired t test; C: Overall survival of patients with GTF3A negative (n = 25) or GTF3A positive (n = 56) expression was analyzed by log-rank (Mantel-Cox) test. ^bP < 0.01; ^cP < 0.001. GTF3A: Transcriptional factor III A; HSCORE: Semi-quantitative histological score.