Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers

doi:10.4251/wjgo.v14.i10.1892

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Oct 15, 2022 (publication date) through Jul 16, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Oct 15, 2022; 14(10): 1892-1902
Published online Oct 15, 2022. doi: 10.4251/wjgo.v14.i10.1892

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Figure 3 The participating pathways of Go-Ichi-Ni-San 2. GINS2: Go-Ichi-Ni-San 2; MAPK: Mitogen-activated protein kinase; ERK: Extracellular signal-regulated kinase; STAT: Signal transducers and activator; EMT: Epithelial-mesenchymal transition; MAPKKK: MAP kinase kinase kinase; MMPs: Matrix metalloproteinases; MEK: Mitogen-activated protein kinase; MKK3/6: MAP kinase kinase 3/6; MCM2: Minichromosome maintenance complex component 2; CHEK2: Checkpoint kinase 2; ATM: Ataxia telangiectasia mutated; CHK2: Cell kinase cyclecheckpoint2; PTP4A1: Protein tyrosine phosphatase 4A1; CITED2: Cbp/P300-interacting transcription factor 2; LOXL2: Lysyl oxidase like 2; GADD45A: Growth arrest and DNA damage inducible alpha; JAK: Janus kinase; mTOR: Mammalian target of rapamycin.

Citation: Shan DD, Zheng QX, Chen Z. Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers. World J Gastrointest Oncol 2022; 14(10): 1892-1902
URL: https://www.wjgnet.com/1948-5204/full/v14/i10/1892.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i10.1892