Long-term follow-up of HER2 overexpression in patients with rectal cancer after preoperative radiotherapy: A prospective cohort study

Table 2 Correlations among HER2 expression and the clinicopathological parameters

Variable	HER2- (%)	HER2+ (%)	χ2	P value
Age (yr)			0.558	0.455
< 60	74 (59.7)	14 (51.9)
≥ 60	50 (40.3)	13 (48.1)
Sex			2.166	0.141
Male	73 (58.9)	20 (74.1)
Female	51 (41.1)	7 (25.9)
Pre-CEA			0.045	0.832
Normal range	80 (64.5)	18 (66.7)
Elevated	44 (35.5)	9 (33.3)
Distance to anal verge (cm)			0.236	0.627
> 6	38 (30.6)	7 (25.9)
≤ 6	86 (69.4)	20 (74.1)
Pre-T				0.6941
T1-2	11	1
T3-4	113	26
Pre-N			4.235	0.040
N0	27 (21.8)	11 (40.7)
N+	97 (78.2)	16 (59.3)
Post-T			1.583	0.208
T1-2	53	8
T3-4	71	19
Post-N			1.582	0.208
N0	76 (61.3)	13 (48.1)
N+	48 (38.7)	14 (51.9)
LVI
+	17 (13.7)	3 (11.1)	0.002	0.9622
-	107 (86.3)	24 (88.9)
Distant metastasis			9.959	0.002
+	42 (33.9)	18 (66.7)
-	82 (66.1)	9 (33.3)
Local recurrence			1.083	0.2982
+	22 (17.7)	2 (7.4)
-	102 (82.3)	25 (92.6)

¹Fisher’s exact test.

²Logistic regression model.

LVI: Lympho-vascular invasion.