Overexpression of ELL-associated factor 2 suppresses invasion, migration, and angiogenesis in colorectal cancer

Table 3 Univariate and multivariate survival analyses of overall survival for colorectal cancer by Cox regression

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (yr) (≥ 61/< 61)	1.203	0.633-2.284	0.573
Gender (female/male)	0.894	0.472-1.695	0.732
Tumor site (colon/rectum)	1.524	0.791-2.935	0.208	0.682	0.288-1.618	0.386
Size of the tumor, cm (> 4/≤ 4)	0.929	0.479-1.799	0.827
Histological type (mucinous/non-mucinous)	1.481	0.619-3.544	0.378
Degree of differentiation (poor/mucinous, well/moderate)	0.863	0.446-1.670	0.661
Angiolymphatic and/or perineural invasion (present/absent)	0.342	0.169-0.693	0.003	0.194	0.036-1.042	0.056
Tumor stage (III-IV/I-II)	0.404	0.200-0.816	0.012	4.199	0.603-29.234	0.147
Tumor invasion depth (T4/T2-T3)	0.426	0.221-0.822	0.011	0.253	0.071-0.908	0.035
Lymph node status (N1-N2/N0)	0.447	0.231-0.867	0.017	3.138	0.766-12.863	0.112
Distant metastasis (present/absent)	0.203	0.105-0.393	< 0.001	0.149	0.056-0.397	< 0.001
EAF2 (low/high)	3.481	1.069-11.341	0.038	2.261	0.653-7.829	0.198
CEA (high/low)	1.092	0.559-2.136	0.796
CA19-9 (high/low)	0.740	0.378-1.446	0.378
P53 (high/low)	0.579	0.295-1.134	0.111	0.697	0.336-1.448	0.333
CDX2 (high/low)	0.694	0.305-1.576	0.383

HR: Hazard ratio; CI: Confidence interval; EAF2: ELL-associated factor 2; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9.