VCAN, expressed highly in hepatitis B virus-induced hepatocellular carcinoma, is a potential biomarker for immune checkpoint inhibitors

Table 4 Top 20 gene enrichment sets of highly expressed VCAN

Name	Size	ES	NES	NOM P value	FDR Q value
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	96	-0.739	-2.154	< 0.001	5.13E-04
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	56	-0.720	-2.046	< 0.001	5.91E-04
KEGG_ECM_RECEPTOR_INTERACTION	84	-0.716	-2.162	< 0.001	8.55E-04
KEGG_AXON_GUIDANCE	129	-0.695	-2.191	< 0.001	0.0015376
KEGG_DILATED_CARDIOMYOPATHY	90	-0.680	-2.112	< 0.001	4.91E-04
KEGG_APOPTOSIS	87	-0.678	-2.042	< 0.001	6.26E-04
KEGG_CHEMOKINE_SIGNALING_PATHWAY	188	-0.678	-2.127	< 0.001	3.83E-04
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	116	-0.677	-2.187	< 0.001	7.69E-04
KEGG_FOCAL_ADHESION	199	-0.675	-2.148	< 0.001	4.28E-04
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	83	-0.673	-2.128	< 0.001	4.30E-04
KEGG_CELL_ADHESION_MOLECULES_CAMS	131	-0.663	-2.076	< 0.001	7.01E-04
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	213	-0.659	-2.158	< 0.001	6.42E-04
KEGG_GAP_JUNCTION	90	-0.656	-2.052	< 0.001	6.23E-04
KEGG_ENDOCYTOSIS	181	-0.656	-2.084	< 0.001	8.02E-04
KEGG_MELANOGENESIS	101	-0.630	-2.129	< 0.001	4.92E-04
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	114	-0.629	-2.097	< 0.001	7.21E-04
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	264	-0.625	-2.119	< 0.001	3.44E-04
KEGG_PATHWAYS_IN_CANCER	325	-0.621	-2.111	< 0.001	4.50E-04
KEGG_MAPK_SIGNALING_PATHWAY	267	-0.602	-2.080	< 0.001	7.48E-04
KEGG_CALCIUM_SIGNALING_PATHWAY	177	-0.582	-2.057	< 0.001	6.60E-04

ES: Enrichment score; NES: Normalized enrichment score; NOM: Nominal; FDR: False discovery rate; KEEG: Kyoto Encyclopedia of Genes and Genomes.