VCAN, expressed highly in hepatitis B virus-induced hepatocellular carcinoma, is a potential biomarker for immune checkpoint inhibitors

doi:10.4251/wjgo.v14.i10.1933

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Oct 15, 2022; 14(10): 1933-1948
Published online Oct 15, 2022. doi: 10.4251/wjgo.v14.i10.1933

Table 1 Correlation between VCAN expression and clinical characteristics in The Cancer Genome Atlas Liver Hepatocellular Carcinoma

Characteristic	Low VCAN	High VCAN	P value
n	187	187
Age, n (%)			0.020
60	77 (20.6)	100 (26.8)
> 60	110 (29.5)	86 (23.1)
Gender, n (%)			0.015
Female	49 (13.1)	72 (19.3)
Male	138 (36.9)	115 (30.7)
Pathologic stage, n (%)			0.042
I & II	138 (39.4)	122 (34.8)
III & IV	41 (11.7)	45 (14.0)
Histologic grade, n (%)			0.090
G1	34 (9.2)	21 (5.7)
G2	88 (23.8)	90 (24.4)
G3	54 (14.6)	70 (19)
G4	8 (2.2)	4 (1.1)
AFP (ng/mL), median (IQR)	9 (3.5, 140)	23 (5, 419)	0.039

AFP: Alpha-fetoprotein; IQR: Interquartile range.

Citation: Wang MQ, Li YP, Xu M, Tian Y, Wu Y, Zhang X, Shi JJ, Dang SS, Jia XL. VCAN, expressed highly in hepatitis B virus-induced hepatocellular carcinoma, is a potential biomarker for immune checkpoint inhibitors. World J Gastrointest Oncol 2022; 14(10): 1933-1948
URL: https://www.wjgnet.com/1948-5204/full/v14/i10/1933.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i10.1933