Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

Figure 7 Nomograms for predicting overall survival and recurrence-free survival after surgical intervention of right-sided colorectal cancer patients. A: The 4-year probability of overall survival was estimated by summing the scores of peritumour (pt) lymphocyte-to-monocyte ratio (LMR), CD8⁺-lymphocyte (CD8)⁺-lymphocyte-to-monocyte ratio (CD8MR)_pt, CD4⁺ plus CD8⁺-lymphocyte (CD4CD8)_pt, blood (b) LMR/LMR_pt, LMR_b/CD8MR _pt, and CD8_pt; B: The 4-year probability of recurrence-free survival was estimated by summing the scores of LMR_pt, LMR_b/LMR_pt, and LMR_b/CD8⁺-lymphocyte-to-monocyte ratio_pt. For each graph, locate the patient’s values for each variable at one of the extremes of its corresponding axis, taking into account the correct position with respect to the optimal cutoff that is indicated; values higher than the cutoff go to the upper end and values lower than the cutoff go to the lower end. Then, draw a line straight upwards to the “Points” axis to determine the score associated to each variable. Add up all the scores, locate this sum in the “Total points” axis and draw a line straight down to the lowest axes of “4-year overall survival” or “4-year recurrence-free survival” to find the predictive probability of the patient for overall survival or recurrence-free survival outcome, respectively.