Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

Figure 2 Leukocyte ratios in peripheral blood and tissues from colorectal cancer patients. A-C: Blood circulating leukocytes in right-sided colorectal cancer (CRC) patients (orange, n = 43) and left-sided CRC patients (green, n = 22) represented as lymphocyte-to-monocyte ratio (LMR)_{blood (b)} (A), neutrophil-to-lymphocyte ratio (B), and platelet-to-lymphocyte ratio (C) (^aP < 0.05, unpaired t test, data are mean ± standard deviation); D-F: Tissue-infiltrated leukocytes in right-sided CRC tumours (tumour [t], orange, n = 34) and peritumours (peritumour [pt], light red, n = 34) and left-sided CRC tumours (t, green, n = 20) and peritumours (pt, light green, n = 20), represented as LMR_t/pt (D), CD4⁺-lymphocyte-to-monocyte ratio (CD4MR)_t/pt (E), and CD8⁺-lymphocyte-to-monocyte ratio (CD8MR)_t/pt (F) (^aP < 0.05, ^bP < 0.01, unpaired Mann-Whitney U test, data are mean ± standard deviation); G-I: Blood-to-tissue leukocyte ratios for right-sided CRC tumours (t, orange, n = 34) and peritumours (pt, light red, n = 34) and left-sided CRC tumours (t, green, n = 20) and peritumours (pt, light green, n = 20) represented as LMR_b/LMR_t/pt (G), LMR_b/CD4MR_t/pt (H), and LMR_b/CD8MR_t/pt (I) (^aP < 0.05, ^bP < 0.01, unpaired Mann-Whitney U test, data are mean ± standard deviation). PLR: Platelet-to-lymphocyte ratio.