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©The Author(s) 2022.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 90-109
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.90
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.90
Table 5 Examples of epigenetic drugs in gastric cancer
Drugs | Targets | Status | Ref. |
Clinical | |||
Vorinostat + capecitabine + cisplatin | HDAC | Completed phase II test | [167] |
Vorinostat + folinic acid+ 5‑fluorouracil+ irinotecan | HDAC | Completed phase I test | [168] |
Azacytidine + epirubicin/oxaliplatin/capecitabine | DNMT | Completed phase I test | [169] |
Cholecalciferol + HDACi | HDAC | Induce apoptosis in GC cells; Prevent bone loss in preliminary trials; | [170,171] |
Preclinical | |||
SAHA | HDAC | Suppress proliferation, induce apoptosis, chemosensitivity in GC cells | [172,173] |
LBH589 | HDAC | Suppress proliferation, induce chemosensitivity | [174,175] |
Resveratrol | HAT, HDAC | Suppress proliferation, invasion, tumorigenesis in GC cells | [176,177] |
Curcumin | HAT, HDAC | Suppress viability, proliferation, migration, induce autophagy, apoptosis in GC cells | [178,179] |
Quercetin | HAT, HDAC | Induce apoptosis, cell cycle arrest in GC cells | [180,181] |
Garcinol | HAT, HDAC, SIRTUIN | Suppress oxidation, inflammation, tumorigenesis in GC cells | [182,183] |
Sodium butyrate | HAT, HDAC | Induce apoptosis in GC cells | [184] |
Tenovin 6 | SIRTUIN | Induce apoptosis, autophagy in GC cells | [185] |
DZNEP | HMT | Suppress proliferation, apoptosis, invasion, induce apoptosis in GC cells | [186,187] |
GSK126 | HMT | Suppress proliferation, cell cycle angiogenesis EMT, tumorigenesis in GC cells | [188,189] |
Compound 26 | Lysine demethylase | Suppress growth, migration, invasion in GC cells | [190] |
- Citation: Tang SY, Zhou PJ, Meng Y, Zeng FR, Deng GT. Gastric cancer: An epigenetic view. World J Gastrointest Oncol 2022; 14(1): 90-109
- URL: https://www.wjgnet.com/1948-5204/full/v14/i1/90.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v14.i1.90