Gastric cancer: An epigenetic view

Table 3 Important circRNAs and their targets and biological functions in gastric cancer

circRNAs	Expression	Targets	Functions	Ref.
circFAM73A	Up	miR-490-3p/ HMGA2	Cell proliferation, migration, CSC-like properties, chemosensitivity	[132]
circAFF2	Up	miR-6894-5p/ANTXR1	Cell proliferation, migration, invasion	[133]
circHIPK3	Up	miR-637 /AKT1	Tumorigenesis	[134]
circVAPA	Up	miR-125b-5p/STAT3	Chemosensitivity	[135]
circMAP7D1	Up	HER2	Cell proliferation, apoptosis	[136]
circ_0006282	Up	miR-144-5p/YWHAB	Cell proliferation, metastasis	[137]
circ_0081146	Up	miR-144/ HMGB1	Cell growth, migration, invasion	[138]
circ_SMAD4	Up	miR-1276/ CTNNB1	Tumorigenesis	[139]
circNEK9	Up	miR-409-3p/MAP7	Cell proliferation, migration, invasion	[140]
circ_0004104	Up	miR-539-3p/RNF2	Cell proliferation, metastasis, glutaminolysis	[141]
circPVT1	Up	miR-152-3p	Chemosensitivity	[142]
hsa_circ_0023409	Up	miR-542-3p/ IRS4	Cell proliferation, metastasis	[143]
circ_0044516	Up	miR-149-5p/HuR	Cell proliferation, migration, invasion, tumor growth	[144]
circLMO7	Up	miR-30a-3p/ WNT2	Cell growth, metastasis	[145]
hsa_circ_0001829	Up	miR-155-5p/SMAD2	Cell growth, metastasis	[146]
circCUL3	Up	miR-515-5p/STAT3/HK2	Cell proliferation, glucose consumption, lactate production, ATP quantity	[147]
circTMEM87A	Up	miR-142-5p/ULK1	Cell proliferation, metastasis	[148]
circPTPN22	Down	EMT	Cell proliferation, migration, EMT, invasion	[149]
hsa_circ_0004872	Down	miR-224/Smad4/ADAR1	Cell proliferation, migration, invasion, tumor growth, metastasis	[150]
hsa_circRNA_0009172	Down	miR-485-3p/NTRK3	Cell proliferation, migration, invasion, tumor growth	[151]
circ_002059	Down	miR-182/ MTSS1	Cell proliferation, migration	[152]
circ-ITCH	Down	miR-199a-5p/ Klotho	Metastasis	[153]
circCUL2	Down	miR-142-3p/ ROCK2	Cell transformation, chemosensitivity, tumorigenesis	[154]