Gastric cancer: An epigenetic view

Table 2 Important lncRNAs and their targets and biological functions in gastric cancer

LncRNAs	Expression	Targets		Functions	Ref.
MIAT	Up		miR-29a-3p/HDAC4	Cell proliferation, migration and invasion	[106]
PANDAR	Up		CDKN1A	Tumor growth	[107]
FOXD2-AS1	Up		EphB3	Tumorigenesis	[108]
SMARCC2	Up		miR-551b-3p/TMPRSS4	Cell proliferation, migration	[109]
H19	Up		miR-519d-p/LDHA	Aerobic glycolysis, proliferation, and immune escape	[110]
TINCR	Up		STAU1/CDKN2B	Cell proliferation, cell cycle	[111]
CCAT2	Up		E-cadherin, LATS2	Cell proliferation, invasion	[112]
AOC4P	Up		Vimentin, MMP9	Cell proliferation, migration, invasion	[113]
CTC-497E21.4	Up		miR-22-3p/NET1	Cell cycle, proliferation, invasion	[114]
BANCR	Up		ERK1/2, NF-κB1	Cell proliferation, apoptosis, chemosensitivity	[115,116]
HOTTIP	Up		miR-216a-5p, miR-615-3p	Chemosensitivity, cell proliferation, apoptosis	[117,118]
AC100830.4, CTC-501O10.1, RP11-210K20.5	Up		-	Differentially expressed in GC and normal tissue	[119]
INHBA-AS1, CEBPA-AS1, AK001058	Up		-	Differentially expressed in GC and normal tissue	[120]
CYTOP	Up		miR-103/RAB10	Cell proliferation, migration, apoptosis	[121]
NKX2-1-AS1	Up		SERPINE1/VEGFR-2	Cell proliferation, angiogenesis	[122]
NEAT1	Up		miR-17-5p/TGFβR2	Angiogenesis	[123]
ZFAS1	Up		EPAS1	Recurrence, metastasis	[124]
TSPEAR-AS2	Up		EZH2/GJA1, miR-1207-5p/CLDN4	Tumor progression	[125]
TMEM92-AS1	Up		YBX1/CCL5	Tumor progression	[126]
CRNDE	Down		NEDD4-1/PTEN	Chemosensitivity	[127]
MEG3	Down		miR-181a-5p/ ATP4B	Cell proliferation, migration, apoptosis	[128]
PCSK2-2:1	Down		-	Differentially expressed in GC and normal tissue	[129]
GNAQ-6:1	Down		-	Differentially expressed in GC and normal tissue	[130]
CTSLP4	Down		Hsp90α/HNRNPAB	Cell migration, invasion, EMT	[131]