Bromodomain and extra-terminal inhibitors emerge as potential therapeutic avenues for gastrointestinal cancers

Table 2 Clinical trials of Bromodomain and extra-terminal inhibitors in gastrointestinal cancers (Trial ID on www.clinicaltrials.gov)

Drug	Combination with	Condition	Status	Clinical phase	Trial ID
INCB054329	-	Solid Tumors and Hematologic Malignancy (CRPC, BC, HGSC, CRC, Ewing sarcoma, Pancreatic adenocarcinoma, AML, MDS, MF, MM)	Terminated due to PK variability	Phase I/II	NCT02431260
INCB057643	Gemcitabine; Paclitaxel; Rucaparib; Abiraterone; Ruxolitinib; Azacitidine	Solid Tumors (CRPC, BC, HGSC, CRC, Glioblastoma multiforme, Ewing sarcoma, Pancreatic adenocarcinoma, AML, MDS)	Terminated due to safety issues	Phase I/II	NCT02711137
AZD5153	Olaparib	Malignant Solid Tumors, Lymphoma, Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer	Active, not recruiting	Phase I	NCT03205176
I-BET762 (Molibresib, GSK525762)	Entinostat	Solid tumors (Advanced Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm, Refractory Pancreatic Carcinoma, Stage II/IIA/IIB/III/IV Pancreatic cancer AJCC v8, Unresectable Pancreatic Carcinoma) or Lymphomas	Withdrawn (Other-Protocol moved to Disapprove)	Phase I	NCT03925428
SF1126	-	Advanced Hepatocellular Carcinoma	Active, not recruiting	Phase I	NCT03059147