Review
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 55-74
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.55
Table 4 Association with Helicobacter pylori infection and Esophageal cancer

Prevalence of H. pylori
Diagnostic tool of H. pylori
Study design
P value
Rokkas et al[44]EAC: 0.52 (95%CI: 0.37-0.73)Serology and/or histologyMeta-analysisEAC: P < 0.001
ESCC: 0.85 (95%CI: 0.55-1.33)ESCC: P = 0.48
Islami et al[45]EAC: 0.56 (95%CI: 0.46-0.68)Serology and/or histologyMeta-analysisNA
ESCC: 1.10 (95%CI: 0.78-1.55)
Nie et al[46]EAC: 0.57 (95%CI: 0.44-0.73)Serology and/or histology; rapid urease testMeta-analysisNA
ESCC:1.16 (95%CI: 0.8.-1.60)
Xie et al[47]EAC: 0.59 (95%CI: 0.51-0.68)Serology and/or histology; rapid urease testMeta-analysisNA
ESCC: 0.97 (95%CI: 0.76-1.24)
ESCC in Eastern: 0.66 (95%CI: 0.43-0.89)