Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases: From the oral cavity to rectum

Table 3 Association with Helicobacter pylori infection and pharyngeal-laryngeal cancer

	Prevalence of H. pylori	Diagnostic tool of H. pylori	Study design	P value
Zhou et al[30]	Laryngeal CA: OR: 3.28; 95%CI: 1.91-5.63	Histochemical, PCR, rapid urease test	Meta-analysis	< 0.0001
	Pharyngeal CA: OR: 1.35; 95%CI: 0.86-2.12			= 0.188
Siupsinskiene et al[31]	Laryngeal CA: Case 46.2% and controls 9.1%	Rapid urease test	Case- control study	< 0.05
Zhou et al[32]	Laryngeal CA: OR: 2.3 95%CI: 1.28-3.23	Serology, histopathological methods	Meta-analysis	< 0.01
Pirzadeh et al[34]	Laryngeal CA: Case 49.2% and controls 40%	Rapid urease test	Case- control study	NA

OR: Odds ratio; CI: Confidence interval; PCR: Polymerase chain reaction; H. pylori: Helicobacter pylori; CA: Cancer; NA: Not available.