Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases: From the oral cavity to rectum

Table 2 Helicobacter pylori infection effect in whole gastroenterology tract malignant diseases

Site	Malignant cell type	H. pylori effect	Odds ratio	95%CI	P value	Gastrointestinal transit time
Oral cavity	Squamous cell carcinoma	Non related				1 min
Pharynx-larynx	Squamous cell carcinoma	Increased risk1	2.87	1.71-4.84	< 0.05	1 s
Oesophagus	Squamous cell carcinoma	Non related				4-8 s
	Adenocarcinoma	Protected effect	0.56	0.46-0.68	< 0.05
Stomach	Adenocarcinoma	Cause-effect	5.9	3.4-10.3	< 0.05	2-4 h
	MALT lymphoma	Cause-effect	1.96	1.0-3.9	< 0.05
Small intestine	Lymphoma	Non related				6 h
Colorectum	Adenocarcinoma	Partial cause-effect	1.7	1.64-1.76	< 0.05	10 h to days
	Lymphoma	Non related

¹Influence of smoking and alcohol consumption on Helicobacter pylori and laryngeal carcinoma was not removed from their study. CI: Confidence interval; MALT: Mucosa-associated lymphoid tissue; H. pylori: Helicobacter pylori.