Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

Table 4 Univariate and multivariate analyses for prognostic variables of recurrence-free survival after surgical interventions of right-sided colorectal cancer and left-sided colorectal cancer

	Total patients	Univariate analysis					Multivariate analysis
	n (%)	HR	95%CI		P		HR	95%CI		P
Variables			Low	High				Low	High
LMRb
Right	34 (63.0)	0.865	0.593	1.262	0.453
Left	20 (37.0)	0.977	0.770	1.239	0.848		0.156	0.001	24.118	0.470
NLRb
Right	34 (63.0)	1.135	0.841	1.532	0.407		2.760	1.050	7.254	0.039	< 0.05
Left	20 (37.0)	1.094	1.094	1.180	0.020	< 0.05	1.156	1.038	1.288	0.009	< 0.01
PLRb
Right	34 (63.0)	1.001	0.996	1.007	0.596		0.978	0.958	0.999	0.037	< 0.05
Left	20 (37.0)	1.002	1.000	1.004	0.018	< 0.05	0.987	0.954	1.022	0.468
CD4t
Right	34 (63.0)	1.010	0.864	1.181	0.902		0.802	0.457	1.407	0.441
Left	20 (37.0)	0.981	0.617	1.559	0.934
CD4pt
Right	34 (63.0)	0.963	0.851	1.091	0.556		1.486	0.124	17.828	0.755
Left	20 (37.0)	1.120	0.795	1.577	0.516
CD8t
Right	34 (63.0)	0.962	0.872	1.062	0.446		1.821	0.451	7.347	0.400
Left	20 (37.0)	1.032	0.971	1.097	0.310
CD8pt
Right	34 (63.0)	0.906	0.780	1.053	0.199		1.117	0.848	1.472	0.431
Left	20 (37.0)	1.050	0.988	1.115	0.116		1.098	1.015	1.189	0.020	< 0.05
CD4CD8t
Right	34 (63.0)	0.972	0.893	1.058	0.515
Left	20 (37.0)	1.033	0.970	1.100	0.307		0.436	0.198	0.960	0.039	< 0.05
CD4CD8pt
Right	34 (63.0)	0.944	0.857	1.041	0.248
Left	20 (37.0)	1.052	0.992	1.117	0.093		0.008	0.000	1.071	0.053
CD14t
Right	34 (63.0)	1.123	0.949	1.329	0.178		1.467	1.048	2.054	0.026	< 0.05
Left	20 (37.0)	0.918	0.713	1.180	0.502
CD14pt
Right	34 (63.0)	1.075	0.891	1.297	0.449		1.790	0.592	5.406	0.302
Left	20 (37.0)	1.472	1.095	1.978	0.010	< 0.05
LMRt
Right	34 (63.0)	0.555	0.337	0.915	0.021	< 0.05	0.641	0.213	1.926	0.428
Left	20 (37.0)	1.084	0.999	1.176	0.052		0.165	0.003	9.203	0.380
LMRpt
Right	34 (63.0)	0.691	0.458	1.042	0.078		0.312	0.123	0.793	0.014	< 0.05
Left	20 (37.0)	1.066	0.688	1.653	0.775
CD4MRt
Right	34 (63.0)	0.588	0.220	1.572	0.290		0.876	0.382	2.010	0.756
Left	20 (37.0)	0.950	0.381	2.370	0.912
CD4MRpt
Right	34 (63.0)	0.734	0.327	1.648	0.454		7.229	0.515	101.544	0.142
Left	20 (37.0)	0.583	0.199	1.709	0.325
CD8MRt
Right	34 (63.0)	0.497	0.246	1.005	0.052
Left	20 (37.0)	1.083	0.999	1.174	0.052		1.123	1.020	1.238	0.019	< 0.05
CD8MRpt
Right	34 (63.0)	0.584	0.333	1.023	0.060
Left	20 (37.0)	1.191	0.815	1.741	0.365		0.293	0.026	3.345	0.323
LMRb/LMRt
Right	34 (63.0)	1.311	1.013	1.697	0.040	< 0.05
Left	20 (37.0)	0.958	0.730	1.258	0.760
LMRb/LMRpt
Right	34 (63.0)	1.248	0.887	1.756	0.203		0.404	0.169	0.969	0.042	< 0.05
Left	20 (37.0)	1.030	0.787	1.347	0.830		1.132	0.859	1.493	0.378
LMRb/CD4MRt
Right	34 (63.0)	1.012	0.965	1.060	0.632		1.056	0.973	1.146	0.192
Left	20 (37.0)	0.991	0.937	1.048	0.742
LMRb/CD4MRpt
Right	34 (63.0)	1.031	0.948	1.121	0.479		1.393	0.875	2.220	0.163
Left	20 (37.0)	1.023	0.969	1.079	0.412		0.925	0.847	1.011	0.087
LMRb/CD8MRt
Right	34 (63.0)	1.146	1.017	1.292	0.025	< 0.05	1.301	1.078	1.571	0.006	< 0.01
Left	20 (37.0)	0.941	0.775	1.143	0.542		1.036	0.591	1.816	0.903
LMRb/CD8MRpt
Right	34 (63.0)	1.022	0.894	1.169	0.746		1.390	0.304	6.350	0.671
Left	20 (37.0)	0.968	0.844	1.109	0.638		0.847	0.576	1.244	0.397

LMR: Lymphocyte-to-monocyte ratio; NLR: Neutrophil-to-lymphocytes ratio; PLR: Platelet-to-lymphocyte ratio; HR: Hazard ratio; CI: Confidence interval; b: Blood; t: Tumour; pt: Peritumour; CD4MR: CD4⁺-lymphocyte-to-monocyte ratio; CD8MR: CD8⁺-lymphocyte-to-monocyte ratio.