Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

Table 3 Univariate and multivariate analyses for prognostic variables of overall survival after surgical interventions of right-sided colorectal cancer and left-sided colorectal cancer

	Total patients	Univariate analysis					Multivariate analysis
	n (%)	HR	95%CI		P		HR	95%CI		P
Variables			Low	High				Low	High
LMRb
Right	34 (63.0)	0.565	0.325	0.982	0.043	< 0.05	0.133	0.000	71.041	0.529
Left	20 (37.0)	1.141	0.867	1.502	0.346		1.141	0.867	1.502	0.346
NLRb
Right	34 (63.0)	1.416	1.019	1.967	0.038	< 0.05	1.416	1.019	1.967	0.038	< 0.05
Left	20 (37.0)	1.043	0.944	1.152	0.410		1.126	0.987	1.284	0.078
PLRb
Right	34 (63.0)	1.005	1.000	1.011	0.064		0.989	0.719	1.361	0.946
Left	20 (37.0)	1.001	0.999	1.004	0.292		0.997	0.937	1.060	0.912
CD4t
Right	34 (63.0)	0.923	0.638	1.334	0.670
Left	20 (37.0)	0.843	0.493	1.439	0.531
CD4pt
Right	34 (63.0)	0.959	0.817	1.124	0.604
Left	20 (37.0)	0.813	0.454	1.456	0.487
CD8t
Right	34 (63.0)	0.995	0.897	1.105	0.931		1.032	0.913	1.167	0.611
Left	20 (37.0)	0.954	0.860	1.057	0.364
CD8pt
Right	34 (63.0)	0.792	0.617	1.016	0.066		0.800	0.636	1.007	0.058
Left	20 (37.0)	1.018	0.957	1.083	0.570		1.033	0.962	1.110	0.372
CD4CD8t
Right	34 (63.0)	0.987	0.892	1.093	0.806
Left	20 (37.0)	0.937	0.833	1.054	0.277
CD4CD8pt
Right	34 (63.0)	0.891	0.761	1.043	0.150		1.073	0.821	1.401	0.606
Left	20 (37.0)	1.015	0.953	1.082	0.641
CD14t
Right	34 (63.0)	1.048	0.845	1.300	0.670		1.077	0.836	1.388	0.565
Left	20 (37.0)	0.979	0.703	1.362	0.898
CD14pt
Right	34 (63.0)	1.113	0.889	1.394	0.351		1.342	0.987	1.826	0.060
Left	20 (37.0)	1.053	0.723	1.533	0.788		0.700	0.381	1.286	0.250
LMRt
Right	34 (63.0)	0.635	0.365	1.103	0.107
Left	20 (37.0)	1.000	0.908	1.101	0.997		0.976	0.555	1.716	0.933
LMRpt
Right	34 (63.0)	0.416	0.194	0.889	0.024	< 0.05
Left	20 (37.0)	1.030	0.712	1.490	0.876		0.031	0.000	4.228	0.166
CD4MRt
Right	34 (63.0)	0.270	0.039	1.850	0.182
Left	20 (37.0)	0.759	0.146	3.954	0.743
CD4MRpt
Right	34 (63.0)	0.431	0.112	1.660	0.221
Left	20 (37.0)	0.135	0.004	4.148	0.252
CD8MRt
Right	34 (63.0)	0.712	0.364	1.394	0.321
Left	20 (37.0)	1.001	0.910	1.100	0.986
CD8MRpt
Right	34 (63.0)	0.223	0.057	0.872	0.031	< 0.05	0.024	0.001	0.430	0.011	< 0.05
Left	20 (37.0)	1.078	0.775	1.500	0.654
LMRb/LMRt
Right	34 (63.0)	0.957	0.603	1.519	0.853
Left	20 (37.0)	1.163	0.935	1.446	0.175
LMRb/LMRpt
Right	34 (63.0)	1.253	0.824	1.907	0.292
Left	20 (37.0)	1.196	0.845	1.695	0.313
LMRb/CD4MRt
Right	34 (63.0)	1.009	0.950	1.073	0.767		1.282	0.931	1.765	0.128
Left	20 (37.0)	1.027	0.961	1.099	0.428
LMRb/CD4MRpt
Right	34 (63.0)	1.028	0.926	1.142	0.600		1.291	0.447	3.728	0.636
Left	20 (37.0)	1.097	1.011	1.190	0.026	< 0.05	0.991	0.420	2.341	0.984
LMRb/CD8MRt
Right	34 (63.0)	0.973	0.747	1.269	0.842
Left	20 (37.0)	1.103	0.940	1.294	0.229		1.971	0.258	15.069	0.513
LMRb/CD8MRpt
Right	34 (63.0)	1.053	0.880	1.260	0.572		0.484	0.268	0.873	0.016	< 0.05
Left	20 (37.0)	1.026	0.834	1.262	0.812		0.952	0.009	96.530	0.983

LMR: Lymphocyte-to-monocyte ratio; NLR: Neutrophil-to-lymphocytes ratio; PLR: Platelet-to-lymphocyte ratio; HR: Hazard ratio; CI: Confidence interval; b: Blood; t: Tumour; pt: Peritumour; CD4MR: CD4⁺-lymphocyte-to-monocyte ratio; CD8MR: CD8⁺-lymphocyte-to-monocyte ratio.