Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

Table 2 Association of leukocytes counts and ratios with overall and recurrence-free survival

Index	Total patients	4-year OS				4-year RFS
	n (%)	Spearman r	95%CI	P		Spearman r	95%CI	P
LMRb
Right	43 (66.2)	-0.3039	-0.5601 to 0.005346	0.0476	< 0.05	-0.1946	-0.4748 to 0.1214	0.211	NS
Left	22 (33.8)	0.1615	-0.2914 to 0.5553	0.4727	NS	-0.07447	-0.4912 to 0.3700	0.7419	NS
NLRb
Right	43 (66.2)	0.2262	-0.08868 to 0.5000	0.1446	NS	0.1062	-0.2094 to 0.4017	0.498	NS
Left	22 (33.8)	-0.06922	-0.4872 to 0.3746	0.7595	NS	0.1192	-0.3305 to 0.5247	0.5974	NS
PLRb
Right	43 (66.2)	0.2307	-0.08405 to 0.5035	0.1367	NS	0.06684	-0.2470 to 0.3680	0.6702	NS
Left	22 (33.8)	0.1615	-0.2914 to 0.5553	0.4727	NS	0.1192	-0.3305 to 0.5247	0.5974	NS
CD4t
Right	34 (63.0)	-0.05561	-0.3954 to 0.2976	0.7548	NS	0.05447	-0.2986 to 0.3944	0.7596	NS
Left	20 (37.0)	0.01892	-0.4387 to 0.4687	0.9369	NS	-0.0354	-0.4815 to 0.4253	0.8822	NS
CD4pt
Right	34 (63.0)	0.03708	-0.3144 to 0.3796	0.8351	NS	0.07371	-0.2809 to 0.4106	0.6787	NS
Left	20 (37.0)	-0.142	-0.5597 to 0.3334	0.5505	NS	0.3276	-0.1483 to 0.6803	0.1586	NS
CD8t
Right	34 (63.0)	-0.08526	-0.4202 to 0.2702	0.6316	NS	-0.2083	-0.1958 to 0.6531	0.2372	NS
Left	20 (37.0)	0.03784	-0.4233 to 0.4834	0.8741	NS	0.2832	-0.3863 to 0.3074	0.2263	NS
CD8pt
Right	34 (63.0)	-0.1186	-0.4476 to 0.2386	0.504	NS	-0.04486	-0.3863 to 0.3074	0.8011	NS
Left	20 (37.0)	0.3406	-0.1340 to 0.6881	0.1417	NS	0.3186	-0.1581 to 0.6749	0.171	NS
CD4CD8t
Right	34 (63.0)	-0.1372	-0.4626 to 0.2208	0.4392	NS	-0.1955	-0.5084 to 0.1630	0.268	NS
Left	20 (37.0)	0.03784	-0.4233 to 0.4834	0.8741	NS	0.2655	-0.2142 to 0.6420	0.2579	NS
CD4CD8pt
Right	34 (63.0)	-0.07044	-0.4079 to 0.2839	0.6922	NS	-0.009612	-0.3559 to 0.3389	0.957	NS
Left	20 (37.0)	0.3595	-0.1127 to 0.6993	0.1195	NS	0.4425	-0.01421 to 0.7464	0.0507	NS
CD14t
Right	34 (63.0)	0.1891	-0.1695 to 0.5034	0.2842	NS	0.2467	-0.1102 to 0.5472	0.1595	NS
Left	20 (37.0)	0.05677	-0.4076 to 0.4978	0.8121	NS	-0.1239	-0.5470 to 0.3496	0.6028	NS
CD14pt
Right	34 (63.0)	0.3003	-0.05262 to 0.5865	0.0844	NS	0.2596	-0.09658 to 0.5568	0.1382	NS
Left	20 (37.0)	0.5677	0.1533 to 0.8122	0.009	< 0.01	0.6018	0.2035 to 0.8292	0.005	< 0.01
LMRt
Right	34 (63.0)	-0.2929	-0.5812 to 0.06070	0.0927	NS	-0.4775	-0.7075 to -0.1559	0.0043	< 0.01
Left	20 (37.0)	0.07569	-0.3916 to 0.5119	0.7511	NS	0.4425	-0.01421 to 0.7464	0.0507	NS
LMRpt
Right	34 (63.0)	-0.4301	-0.6764 to -0.09719	0.0111	< 0.05	-0.3846	-0.6457 to -0.04285	0.0247	< 0.05
Left	20 (37.0)	0	-0.4538 to 0.4538	> 0.9999	NS	-0.0354	-0.4815 to 0.4253	0.8822	NS
CD4MRt
Right	34 (63.0)	-0.2781	-0.5704 to 0.07674	0.1113	NS	-0.3173	-0.5987 to 0.03388	0.0675	NS
Left	20 (37.0)	0.04736	-0.4154 to 0.4907	0.8428	NS	0.1949	-0.2841 to 0.5960	0.4102	NS
CD4MRpt
Right	34 (63.0)	-0.2781	-0.5704 to 0.07670	0.1112	NS	-0.2596	-0.5568 to 0.09650	0.1381	NS
Left	20 (37.0)	-0.473	-0.7631 to -0.02445	0.0352	NS	-0.0885	-0.5214 to 0.3806	0.7106	NS
CD8MRt
Right	34 (63.0)	-0.2039	-0.5149 to 0.1545	0.2474	NS	-0.4422	-0.6845 to -0.1120	0.0088	< 0.01
Left	20 (37.0)	0.1135	-0.3588 to 0.5396	0.6337	NS	0.4779	0.03071 to 0.7657	0.0331	< 0.05
CD8MRpt
Right	34 (63.0)	-0.3596	-0.6285 to -0.01393	0.0367	< 0.05	-0.2788	-0.5709 to 0.07601	0.1104	NS
Left	20 (37.0)	0.1893	-0.2894 to 0.5923	0.4241	NS	-0.03541	-0.4815 to 0.4253	0.8822	NS
LMRb/LMRt
Right	34 (63.0)	0.1075	-0.2492 to 0.4386	0.545	NS	0.3621	0.01678 to 0.6302	0.0353	< 0.05
Left	20 (37.0)	-0.05677	-0.4978 to 0.4076	0.8121	NS	-0.4248	-0.7366 to 0.03599	0.0619	NS
LMRb/LMRpt
Right	34 (63.0)	0.241	-0.1162 to 0.5430	0.1698	NS	0.2884	-0.06561 to 0.5779	0.0981	NS
Left	20 (37.0)	0.1325	-0.3420 to 0.5531	0.5778	NS	-0.0531	-0.4950 to 0.4106	0.8241	NS
LMRb/CD4MRt
Right	34 (63.0)	0.1372	-0.2208 to 0.4626	0.4392	NS	0.2467	-0.1101 to 0.5473	0.1595	NS
Left	20 (37.0)	-0.09461	-0.5259 to 0.3754	0.6915	NS	-0.177	-0.5839 to 0.3010	0.4554	NS
LMRb/CD4MRpt
Right	34 (63.0)	0.1446	-0.2136 to 0.4685	0.4146	NS	0.189	-0.1695 to 0.5034	0.2843	NS
Left	20 (37.0)	0.4541	0.0003499 to 0.7528	0.0443	< 0.05	0.1062	-0.3653 to 0.5343	0.6559	NS
LMRb/CD8MRt
Right	34 (63.0)	0.04078	-0.3111 to 0.3828	0.8189	NS	0.3364	-0.01245 to 0.6123	0.0517	NS
Left	20 (37.0)	-0.03784	-0.4834 to 0.4233	0.8741	NS	-0.4071	-0.7267 to 0.05735	0.0748	NS
LMRb/CD8MRpt
Right	34 (63.0)	0.1409	-0.2172 to 0.4655	0.4267	NS	0.1859	-0.1727 to 0.5009	0.2926	NS
Left	20 (37.0)	-0.1703	-0.5794 to 0.3073	0.4729	NS	-0.1416	-0.5595 to 0.3337	0.5515	NS

OS: Overall survival; RFS: Recurrence-free survival; LMR: Lymphocyte-to-monocyte ratio; NLR: Neutrophil-to-lymphocytes ratio; PLR: Platelet-to-lymphocyte ratio; b: Blood; t: Tumour; pt: Peritumour; CD4MR: CD4⁺-lymphocyte-to-monocyte ratio; CD8MR: CD8⁺-lymphocyte-to-monocyte ratio; CI: Confidence interval; NS: Not significant.