Characterization of E-cadherin expression in normal mucosa, dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis

Table 4 Univariate and multivariate analyses of survival of patients with gastric cardia adenocarcinoma

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Gender			> 0.05
Female	1
Male	1.063	0.979-1.153
Age at diagnosis (yr)			< 0.001			< 0.001
< 60	1			1
≥ 60	1.335	1.246-1.431		1.352	1.262-1.449
Family history			> 0.05
Negative	1
Positive	1.060	0.983-1.143
Cigarette smoking			> 0.05
No	1
Yes	1.004	0.929-1.084
Alcohol consumption			> 0.05
No	1
Yes	0.947	0.869-1.031
Differentiation			< 0.001			< 0.001
Well	1			1
Moderate	1.316	1.067-1.623		1.234	1.000-1.522
Poor	1.791	1.454-2.206		1.480	1.199-1.827
T status			< 0.001			< 0.001
pT1	1			1
pT2	1.916	1.289-2.849		1.604	1.078-2.387
pT3	2.829	1.949-4.107		2.074	1.426-3.018
pT4	3.390	2.328-4.936		2.272	1.555-3.320
Lymph node metastasis			< 0.001			< 0.001
Negative	1			1
Positive	1.952	1.815-2.099		1.805	1.676-1.944
E-cadherin			0.003			0.026
Positive	1			1
Negative	1.144	1.048-1.248		1.104	1.012-1.206

CI: Confidence interval; GCA: Gastric cardia adenocarcinoma; HR: Hazard ratio.