Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway

Figure 2 Protein-protein interaction network of the 83 predicted targets and scoparone inhibits proliferation. A: Protein-protein interaction (PPI) network of the 83 predicted targets through STRING; B: Visualized PPI network of the 83 predicted targets through Cytoscape 3.7.2. Darker nodes indicate higher degree value; C: Expression patterns of the following candidate hub genes: AKT1, MAPK8, and EGFR; the red represents the tumor group and the gray represents the normal group; D and E: IC₅₀ values of scoparone for Capan-2 and SW1990 cells shown by CCK-8 assay; F and G: Scoparone inhibits the proliferation of Capan-2 and SW1990 cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001 vs the control group.