Prognostic value of modified Lauren classification in gastric cancer

doi:10.4251/wjgo.v13.i9.1184

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2021; 13(9): 1184-1195
Published online Sep 15, 2021. doi: 10.4251/wjgo.v13.i9.1184

Table 2 Univariate and multivariable analyses of prognostic factors for overall survival

Variable	No. of patients (%)	Univariate analysis		Multivariate analysis
Variable	No. of patients (%)	5-yr OS	P value	HR (95%CI)	P value
Gender (%)			0.111
Male	1588 (58.4)	45.9%
Female	1130 (41.6)	49.1%
Age (%)			< 0.001		< 0.001
< 60 yr	1217 (44.8)	50.7%		1 (Ref)	–
≥ 60 yr	1501 (55.2)	44.4%		1.157 (1.360–1.692)	< 0.001
Tumor size (%)			< 0.001		0.001
≤ 4.0 cm	1200 (44.2)	63.9%		1 (Ref)	–
> 4.0 cm	1302 (47.9)	33.6%		1.179 (1.038–1.339)	0.011
Unknown	216 (7.9)	40.2%		1.457 (1.191–1.782)	< 0.001
Retrieved lymph nodes (%)			0.074		< 0.001
Adequate (n ≥ 16)	1418 (52.2)	48.9%		1 (Ref)	–
Inadequate (n < 16)	1300 (47.8)	45.5%		1.550 (1.380–1.740)	< 0.001
AJCC 8^thpT stage (%)			< 0.001		< 0.001
pT1	690 (25.4)	80.9%		1 (Ref)	–
pT2	329 (12.1)	66.6%		1.535 (1.193–1.975)	0.001
pT3	820 (30.2)	38.5%		2.882 (2.334–3.558)	< 0.001
pT4a	670 (24.7)	23.4%		3.415 (2.740–4.256)	< 0.001
pT4b	209 (7.7)	18.6%		4.452 (3.458–5.732)	< 0.001
AJCC 8^thpN stage (%)			< 0.001		< 0.001
pN0	1031 (37.9)	71.6%		1 (Ref)	–
pN1	456 (16.8)	46.9%		1.467 (1.225–1.757)	< 0.001
pN2	507 (18.7)	37.5%		1.611 (1.353–1.919)	< 0.001
pN3a	512 (18.8)	24.8%		2.356 (1.976–2.809)	< 0.001
pN3b	212 (7.8)	9.2%		4.138 (3.306–5.181)	< 0.001
Differentiation grade (%)			0.011		0.135
Well differentiation	95 (3.5)	69.4%		1 (Ref)	–
Moderate differentiation	483 (17.8)	58.9%		0.974 (0.649–1.462)	0.898
Poor differentiation	2054 (75.5)	44.0%		1.123 (0.755–1.670)	0.566
Undifferentiation	86 (3.2)	35.6%		1.415 (0.876–2.285)	0.156
Modified Lauren classification (%)			< 0.001		0.013
Distal non-diffuse type	654 (24.1)	58.8%		1 (Ref)	–
Proximal non-diffuse type	463 (17.0)	48.3%		1.230 (1.033–1.466)	0.020
Diffuse type	1601 (58.9)	42.4%		1.246 (1.068–1.452)	0.005

AJCC: American Joint Committee on Cancer; HR: Hazard ratio; OS: Overall survival; pN stage: Pathological N stage; pT stage: Pathological T stage. Variables with P values less than 0.1 were included in the multivariate analysis.

Citation: Ning FL, Zhang NN, Wang J, Jin YF, Quan HG, Pei JP, Zhao Y, Zeng XT, Abe M, Zhang CD. Prognostic value of modified Lauren classification in gastric cancer. World J Gastrointest Oncol 2021; 13(9): 1184-1195
URL: https://www.wjgnet.com/1948-5204/full/v13/i9/1184.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i9.1184