Role of exosomal long non-coding RNAs in colorectal cancer

Table 3 Exosomal long non-coding RNAs as novel biomarkers and therapeutic targets for colorectal cancer

Exosomal lncRNA	Expression	Relationship with clinicopathologic features	AUC	Ref.
APC1	↑	Lymph node and distant metastasis	-	Wang et al[45]
GAS5	↑	TNM stage, Dukes stage, lymph node metastasis, local recurrence, and distant metastasis	0.791	Xu et al[40]
LINC02418	↑	-	0.898	Zhao et al[42]
SPINT1-AS1	↑	Lymph node metastasis, distant metastasis, and poor RFS	0.865	Li et al[74]
ADAMTS9-AS1	↑	-	0.835	Li et al[47]
CCAT2	↑	TNM stages and lymph node metastasis	-	Wang et al[75]
UCA1	↑	Tumor size, tumor stage, and metastasis status	-	Luan et al[38]
CRNDE-h	↑	Lymph node metastasis and distant metastasis	0.892	Liu et al[76]
CRNDE-p	↑	Advanced clinical stages, tumor classification, and lymph node or distant metastasis	0.854	Yu et al[77]
HOTTIP	↓	Lymph node metastasis and better OS	0.750	Oehme et al[78]
91H	↑	TNM stage	-	Gao et al[48]
RPPH1	↑	TNM stage, metastasis, and poor OS and DFS	0.856	Liang et al[44]
H19	↑	TNM stage	-	Ren et al[37]

LncRNA: Long non-coding RNA; AUC: Area under the curve; OS: Overall survival; TNM: Tumor-node-metastasis; DFS: Disease-free survival.