Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions

doi:10.4251/wjgo.v13.i7.693

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2021; 13(7): 693-705
Published online Jul 15, 2021. doi: 10.4251/wjgo.v13.i7.693

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Figure 7 Mechanism by which cryptotanshinone regulates Src homology 2 domain–containing phosphatase 2 and cytotoxin-associated gene A-associated pathogenesis in gastric cancer. Cryptotanshinone (CTS) suppresses the expression of Src homology 2 domain–containing phosphatase 2 (SHP2), which prevents cytotoxin-associated gene A (CagA) from phosphorylating SHP2. Therefore, CTS inhibits CagA-induced proliferation and the epithelial-mesenchymal transition (EMT) in gastric cancer (GC) and mucosal erosion in the stomach of mice.

Citation: Chen ZM, Hu J, Xu YM, He W, Meng L, Huang T, Ying SC, Jiang Z, Xu AM. Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions. World J Gastrointest Oncol 2021; 13(7): 693-705
URL: https://www.wjgnet.com/1948-5204/full/v13/i7/693.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i7.693